Mechanisms of pHi recovery after global ischemia in the perfused heart.

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Mechanisms of pHi recovery after global ischemia in the perfused heart.

A Na(+)-HCO3- coinflux carrier and the Na(+)-H+ antiport have both been shown to contribute to recovery from intracellular acidosis in cardiac tissue. We have investigated the participation of these mechanisms as well as metabolite (lactate and CO2) washout in the recovery of pHi after myocardial ischemia. Isovolumic ferret hearts were Langendorff-perfused with either HCO3(-)-buffered or nomina...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1993

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.72.5.993